(Reuters) -Moderna Inc said on Monday that a booster dose of its COVID-19 vaccine appeared to be protective against the fast-spreading Omicron variant of the coronavirus in laboratory testing and that the current version of the shot would continue to be its "first line of defense against Omicron."
The company said its decision to focus on the current vaccine, mRNA-1273, was driven in part by how quickly the recently-discovered variant is spreading.
Moderna said it still plans to develop a vaccine to protect against Omicron specifically and hopes to start clinical trials early next year.
"What we have available right now is 1273," Dr. Paul Burton, Moderna's chief medical officer, said in an interview. "It's highly effective, and it's extremely safe. I think it will protect people through the coming holiday period and through these winter months, when we're going to see the most severe pressure of Omicron."
Moderna's shares were down more than 4% at $282.26 in afternoon trading.
The company said a two-dose course of its vaccine generated low neutralizing antibodies against the Omicron variant, but a 50-microgram booster dose increased neutralizing antibodies against the variant 37 fold. A 100-microgram booster - the same strength as the original shots - drove neutralizing antibodies to more than 80 times pre-boost levels.
Moderna President Stephen Hoge on a conference call said the company currently does not plan to pursue approval for the higher booster dose.
The antibody levels generated by the lower dose shot "are comfortably above" what would signify a risk of breakthrough infections for other variants of concern, Hoge said.
Moderna did not specify whether it believes its two-dose regimen will reduce hospitalizations or deaths from the Omicron variant. Studies by other researchers have shown a "reasonable and robust" T cell response is maintained against the variant, Hoge said, which could suggest protection against severe disease. T cells in the immune system recognize and eliminate virus-infected cells.
SOURCE : Yhooo
